The New Evil League of Evil[/u] Dr. Horrible (Dr. Horrible), Deadpool (Marvel), Riddler (DC), Wile E. Coyote (Looney Tunes), Brainiac (DC), Mysterio (Marvel)
vs.
Doom's Cabal[/u] Dr. Doom (Marvel), Dark Willow (Buffy the Vampire Slayer), Storm Shadow (GI Joe), Crowley (Supernatural), Kraven (Marvel), Dr. Wily (Mega Man)
Dr. Horrible is obviously the team leader. Deadpool is the spy/intelligence/assassin. Riddler is the crypto/puzzle solver. Wile E. is the demolitions expert. Brainiac is the super hacker. And Mysterio is the official comic relief of the team.